孙玥

孙玥 Yue Sun
办公电话:0411-82153999
邮箱:sunyue01@lnnu.edu.cn
履历
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球友会,理学博士(2016)
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球友会,讲师(2016-2023)
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球友会,副教授(2024至今)
研究方向
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基于天然活性多肽构效关系的药物设计及应用研究
招生方向
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生物化学及分子生物学
代表性论文
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Yue Sun#, Dejing Shang*. Inhibitory effects of antimicrobial peptides on lipopolysaccharide-induced inflammation. Mediators of Inflammation, 2015, 2015: 167572.
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Yue Sun#, Weibing Dong#, Li Sun, Lijie Ma, Dejing Shang*. Insights into the membrane interaction mechanism and antibacterial properties of chensinin-1b. Biomaterials, 2015, 37: 299-311.
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Weibing Dong#, Yue Sun#, Dejing Shang*.Interactions between chensinin-1, a natural antimicrobial peptide derived from Rana Chensinensis, and lipopolysaccharide. Biopolymers, 2015, 103(12): 719-726.
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Weibing Dong#, Xueyue Luo#, Yue Sun#, Yue Li, Cui Wang, Yue Guan, Dejing Shang*. Binding Properties of DNA and Antimicrobial Peptide Chensinin-1b Containing Lipophilic Alkyl Tails. Journal of Fluorescence, 2020, 30(1):131-142.
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Juan Zhang#, Yue Sun#, Yao Kang, Dejing Shang*. Antimicrobial peptide temporin-1CEa isolated from frog skin secretions inhibits the proinflammatory response in lipopolysaccharide-stimulated RAW264.7 murine macrophages through the MyD88-dependent signaling pathway. Molecular Immunology, 2021, 132: 227-235.
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Yue Li#, Yue Sun#, Weibing Dong, Chengdong Zhu, Yue Guan, Dejing Shang*. Acylation of antimicrobial peptide-plasmid DNA vectors formulation for efficient gene delivery in cancer therapy [J]. Colloids and Surfaces B: Biointerfaces, 2021, 208: 112069-112069.
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Yue Guan#, Yue Sun#, Dejing Shang*. Amine-functionalized POSS cross-linked the poly(imide siloxane) block copolymers nanocomposites: preparation, thermal properties, against atomic oxygen erosion. Journal of Macromolecular Science, Part A: Pure and Applied Chemistry, 2022, 59(3): 241-248.
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Zhenjia Li, Wenzhi Qu, Dongdong Zhang, Yue Sun*, Dejing Shang*. The antimicrobial peptide chensinin-1b alleviates the inflammatory response by targeting the TLR4/NF-κB signaling pathway and inhibits Pseudomonas aeruginosa infection and LPS-mediated sepsis. Biomed Pharmacother, 2023, 165: 115227.
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Yue Sun#, Huiyu Li, Xingpeng Duan, Xiaoxiao Ma, Chenxi Liu, Dejing Shang*. Chensinin-1b Alleviates DSS-Induced Inflammatory Bowel Disease by Inducing Macrophage Switching from the M1 to the M2 Phenotype. Biomedicines, 2024, 12(2):345.
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Jinyu Zhang#, Fengling Yang, Dahai Tang, Zengfa Wang, Kejin He, Jingbo Chen, Blessing Danso, Dunbiao Wei, Juan Hofer, Yue Sun*, Liang Xiao*, Weibing Dong*. Sika Deer antler protein antagonizes the inflammatory response and oxidative damage induced by jellyfish venom. International Immunopharmacology, 2024,143 (Pt 1): 113343.
开设课程
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遗传学(本科生)
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遗传学实验(本科生)
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文献检索与论文写作(本科生)
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现代生物学进展 (研究生)
科研课题
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国家自然科学基金青年科学项目(31702023),两栖类皮肤抗菌肽chensinin-1b对巨噬细胞极化功能调控作用及其分子机制研究,2018-2020,主持
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辽宁省科技厅项目(20170520290),抗菌肽chensinin-1b调节巨噬细胞极化状态及其载炎症反应中的作用,2017-2019,主持
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大连市青年科技之星项目(2021RQ024),东北林蛙皮肤抗菌肽chensinin-1b及类似物调控糖尿病肾病中巨噬细胞极化失衡的应用研究,2022-2023,主持
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国家自然科学基金面上项目(32070440),两栖类皮肤抗菌肽chensinin-1b抗动脉粥样硬化的分子机制研究,2021-2024,参与
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国家自然科学基金面上项目(31872225),两栖类皮肤抗菌肽chensinin-1b自组装纳米结构的构建、体内稳定性及抗菌作用机制研究,2019-2022,参与
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国家自然科学基金面上项目(31672289),具有任意伸展结构的两栖类皮肤抗菌肽chensinin-1b抗LPS引起的感染性休克与免疫调节的分子机制研究,2017-2020,参与
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国家自然科学基金青年科学基金项目(21502083),抗酶解的抗菌肽chensinin-1b类肽化合物的设计合成、抗菌活性及其作用机制研究,2016-2018,参与
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国家自然科学基金面上项目(31272314),具有任意伸展结构的新型两栖类皮肤抗菌肽的构效关系及于生物膜作用的分子机制,2013-2016,参与