履历

• 球友会生物教育专业，获理学学士学位（1994.9-1998.6）
• 球友会植物基因工程专业，获理学硕士学位（1998.9-2001.6）
• 大连理工大员工物化工专业，获工学博士学位（2004.9-2008.3）
• 球友会助教、讲师、副教授、教授（2001.7至今）
• 球友会硕士生导师（2010.8至今）

研究方向

代表性论文

• Zhang, M., Li, W., Zhang, X., Bi, M., Wang, X., Sun, F., Lu, J., Chi, Y., Han, Y., Li, Q., & Li, T*. (2024). Lamprey VDAC2: Suppressing hydrogen peroxide-induced 293T cell apoptosis by downregulating BAK expression. Fish & shellfish immunology, 150, 109622.
• Zhu, Y., Zhang, Q., Pan, J., Li, T., Wang, H., Liu, J., Qian, L., Zhu, T., Pang, Y., Li, Q., & Chi, Y. (2024). Evolutionary analysis of SLC10 family members and insights into function and expression regulation of lamprey NTCP. Fish physiology and biochemistry, 50(3), 1109–1122.
• Zhang, X., Zhao, J., Li, Q., Qin, D., Li, W., Wang, X., Bi, M., Li, Q., & Li, T*. (2023). Lamprey prohibitin 2 inhibits non-small cell lung carcinoma cell proliferation by down-regulating the expression and phosphorylation levels of cell cycle-associated proteins. Fish & shellfish immunology, 134, 108560.
• Zheng K, Li T*. Prediction of ATPase cation transporting 13A2 molecule in Petromyzon marinus and pan-cancer analysis into human tumors from an evolutionary perspective[J]. Immunogenetics. 2021;73(4):277-289.
• Xu X, Ma A, Li T, et al. Genetic and Functional Characterization of Novel Brown-Like Adipocytes Around the Lamprey Brain[J]. Front Cell Dev Biol. 2021;9:674939.
• Guo Y, Li T, Li Q, Pang Y, Su P. A novel protein upstream stimulatory factor 2 identified in lamprey, Lethenteron reissneri[J]. Dev Genes Evol. 2020;230(5-6):347-357.
• Ying Shi, Feng Sun, Chenyue Zhu, Sainan Ma, Di Qin, Qingwei Li, Tiesong Li*. Lamprey PHB2 maintains mitochondrial stability by tanslocation to the mitochondria under oxidative stress[J]. Fish and Shellfish Immunology, 2020, 104:613–621.
• Ying Shi, Sicheng Guo, Ying Wang, Xin Liu, Qingwei Li*, Tiesong Li*.  Lamprey Prohibitin2 Arrest G2/M Phase Transition of HeLa Cells through Down-regulating Expression and Phosphorylation Level of Cell Cycle Proteins[J]. Scientific Reports, 2018,8(1):3932. 
•  Tiesong Li, Ying Wang, Yang Gao, Qingwei Li*. Identification and Characterisation of the Anti-oxidative Stress Properties of the Lamprey Prohibitin2 Gene[J]. Fish & Shellfish Immunology, 2015,42: 447-456.
• Tong WANG, Yizhi LIANG, Xuhao WANG, Shuxiang NING, Tiesong LI*. Screening algae strains of Chlorella sp. and Dunaliella salina with resistance to oil pollution and their lipid enrichment by using petroleum hydrocarbons[J]. Cahiers de Biologie Marine, 2015, 56:195-203.
• Tiesong Li, Cao Chen, Yang Gao, Qingwei Li*. Cloning and Characterization of a cDNA Encoding Prohibitin1 from Lampetra japonica and Its Expression Analysis[J]. Cellular Molecular Biology, 2012, 58:1791-1796.
• Tiesong Li, Changhai Wang*, Junkui Miao. Identification and Quantification of Indole-3-acetic acid in the Kelp Laminaria japonica Aresch. and Its Effect on Growth of Marine Microalgae[J]. Journal of Applied Phycology, 2007,19:479-484.
• Yinglun Han, Xin Liu, Peng Dai, Chunhui Zhao, Tiesong Li, Jihong Wang, Rong Xiao, Qingwei Li*. A novel member of lymphocyte-specific protein tyrosine kinase protein identified in lamprey, Lampetra japonica[J]. Acta Biochimica et Biophysica Sinica, 2014,46(9):820-825.
• Li B, Gou M, Han J, Yuan X, Li Y, Li T, Jiang Q, Xiao R, Li Q. Proteomic analysis of buccal gland secretion from fasting and feeding lampreys (Lampetra morii)[J]. Proteome Sci. 2018 May 22;16:9.
• Li Y, Zhang W, Zuo Y, Zhu T, Pang Y, Li T, Li Q. Label-Free Quantitative Proteomic Reveals Differentially Expressed Proteins in Aeromonas-Immunostimulated Leukocytes of Lampetra japonica[J]. Curr Microbiol. 2018, 75(7):934-941.
• Zuo Y, Xie W, Pang Y, Li T, Li Q, Li Y. Bacterial community composition in the gut content of Lampetra japonica revealed by 16S rRNA gene pyrosequencing[J]. PLoS One. 2017, 12(12):e0188919.
• Xin L, Jie Z, Chunhui Z, Tiesong L, Jihong W, Qingwei L. The identification and verification of species-specific microRNAs and their precursors in Lampetra japonica[J]. Yi Chuan. 2015, 37(3):283-91.
• Han Y, Liu X, Dai P, Zhao C, Li T, Wang J, Xiao R, Li Q. A novel member of lymphocyte-specific protein tyrosine kinase protein identified in lamprey, Lampetra japonica[J]. Acta Biochim Biophys Sin (Shanghai). 2014, 46(9):820-5.
• 赵健竹, 李铁松*, 李庆伟. 抗增殖蛋白在肿瘤发生发展过程中扮演多种角色[J]. 中国生物化学与分子生物学报, 2019,35(10):1086-1093.
• 时颖, 李铁松*, 李庆伟. 抗增殖蛋白2:一种线粒体和细胞核之间的重要媒介[J]. 中国生物化学与分子生物学报, 2018, 34(1):32-37.
• ​郭思呈, 李铁松*, 李庆伟. TMEM16A：一种钙离子激活的氯离子通道[J]. 中国生物化学与分子生物学报, 2017, 33(12):1187-1194.

开设课程

• 《分子生物学》（本科生）：辽宁省一流本科课程（课程负责人）
• 《分子克隆技术》（本科生）
• 《生物学方法论》（本科生）
• 《细胞生物学研究方法》（硕士）
• 《细胞生物学前沿专题》（硕士）
• 《生物教学发展前沿专题》（硕士）

科研课题

• 主持国家自然科学基金青年基金项目“七鳃鳗PHB2增强细胞氧化应激耐受的作用与机制”No:31501907
• 主持辽宁省教育厅科学技术基金项目“七鳃鳗PHB2蛋白抑制人非小细胞肺癌细胞增殖的分子机制”No:LJKZ0989
• 主持辽宁省教育厅科学技术基金项目“七鳃鳗PHB2增强CHL细胞氧化应激耐受的定位迁移机制”No:2015287
• 主持大连市科技基金计划项目“七鳃鳗PHB1过表达对氧化应激心肌细胞的影响”No:2010J21DW018
• 主持教育部博士学科点专项科研基金项目“PHB在七鳃鳗氧化应激心肌和类淋巴细胞中的表达变化”No:20102136120002
• 参与国家科技部重大新药创制专项重大课题“中药雾化吸入制剂吸入给药”No:2017ZX09201002-007,第2参与人

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