史晓霞
史晓霞 Xiaoxia Shi
邮箱：xshi@lnnu.edu.cn
履历
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个人简介：史晓霞，助理副教授，研究方向包括肝脏与胃肠道疾病，恶性肿瘤。现主要从事AAV病毒载体介导的基因治疗用于遗传性肝脏疾病、长链非编码RNA在乳腺癌中的分子机制等方面的研究，目前已发表SCI期刊论文18余篇，其中JCR Q1分区论文9篇，中科院一区TOP期刊4篇。2023年入选Sigma Xi（英文全称：The Scientific Research Honor Society）美国科学研究荣誉学会正式会员，大连市新引进高层次人才（青年才俊）。学习经历：2014-10—2021-04, 荷兰阿姆斯特丹大学, 肝脏与胃肠道疾病研究所，医学，博士 (导师: Prof. Piter Bosma)2011-09—2014-06, 吉林大学, 临床兽医学, 硕士（导师：刘国文 教授）2007-09—2011-07, 安徽科技球友会, 动物医学, 学士（指导员工：宁康健 教授）工作经历：2024-01—至今，球友会，球友会，助理副教授2021-07—2023-12, 大连理工大学，生物工程球友会，博士后
研究方向
- 研究方向包括肝脏与胃肠道疾病，恶性肿瘤。现主要从事腺相关病毒载体（AAV）介导的基因治疗用于遗传性肝脏疾病、长链非编码RNA在乳腺癌中的分子机制等方面的研究，涉及基因编辑（CRISPR/Cas9、Prime Editing），AAV和长链非编码RNA等多个研究领域。
招生专业
- 生物学
代表性论文
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Xiaoxia Shi, Yixin Du, Shujing Li, Huijian Wu*, The Role of SUMO E3 Ligases in Signaling Pathway of Cancer Cells, International Journal of Molecular Science, 2022, 23(7). \
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Giulia Bortolussi#, Xiaoxia Shi#, Lysbeth Bloemendaal, Bhaswati Banerjee, Dirk Waart, Gabriele Baj, Weiyu Chen, Ronald Oude Elferink, Ulrich Beuers, Coen Paulusma, Roland Stocker, Andrés Muro, Piter Bosma*, Long-Term Effects of Biliverdin Reductase a Deficiency in Ugt1-/- Mice: Impact on Redox Status and Metabolism, Antioxidants, 2021, 10.
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Xiaoxia Shi, Sem Aronson, Lysbeth Bloemendaal, Suzanne Duijst, Robert Bakker, Dirk Waart, Giulia Bortolussi, Fanny Collaud, Ronald Oude Elferink, Andrés Muro, Federico Mingozzi, Giuseppe Ronzitti, Piter Bosma*, Efficacy of AAV8-hUGT1A1 with Rapamycin in neonatal, suckling, and juvenile rats to model treatment in pediatric CNs patients, Molecular Therapy-Methods & Clinical Development, 2021, 20: 287-297.
- Xiaoxia Shi*, Giulia Bortolussi, Lysbeth Ten Bloemendaal, Suzanne Duijst, Andrés F Muro, Piter J Bosma, Low efficacy of recombinant SV40 in Ugt1a1-/- mice with severe inherited hyperbilirubinemia., PLoS One, 2021, 16.
- Xiaoxia Shi*, Sem Aronson, AS Khan, Piter J Bosma. A novel UGT1A1 gene mutation causing severe unconjugated hyperbilirubinemia: a case report. BMC Pediatrics. 2019 May, 173.
- Xiaoxia Shi, Matthew Ryan Ykema, Jaco Hazenoot, Lysbeth Bloemendaal, Irene Mancini, Machteld Odijk, Peter Haan, Piter Bosma*, Cre Recombinase Mediates the Removal of Bacterial Backbone to Efficiently Generate rSV40., Molecular Therapy-Methods & Clinical Development, 2018, 9: 225-233.
- Yanan Li#, Shujing Li#, Xiaoxia Shi, Zhiqiang Xin, Yuxi Yang, Binggong Zhao, Yulin Li, linlin Lv, Ping Ren, and Huijian Wu*. KLF12 promotes the proliferation of breast cancer cells by reducing the transcription of p21 in a p53-dependent and p53-independent manner. Cell Death and Disease. 2023 May 8,14(5):313.
- Bowen Li#, Shujing Li#, Xiaoxia Shi, Yini Zhang, Zhiqiang Xin, Yuxi Yang, Binggong Zhao, Ping Ren*, Huijian Wu*. MZF1 (Myeloid Zinc Finger 1) activates transcriptional activity of p53 and suppresses breast cancer cell proliferation via acetyltransferase PCAF (P300/CBP associated factor). Genes & Diseases. 2022, ISSN 2352-3042.
- Kangkai Xia#, Shujing Li#, Yuxi Yang, Xiaoxia Shi, Binggong Zhao, Linlin Lv, Zhiqiang Xin, Jie Kang, Ping Ren* and Huijian Wu*. Cryptochrome 2 acetylation attenuates its antiproliferative effect in breast cancer. Cell Death and Disease. 2023 Apr 6,14(4):250.
- Binggong Zhao#, Wei Huo#, Xiaomin Yu, Xiaoxia Shi, Linlin Lv, Yuxi Yang, Jie Kang, Shujing Li, Huijian Wu*. USP13 promotes breast cancer metastasis through FBXL14 induced Twist1 ubiquitination. Cellular Oncology. 2023 Feb 3.
- Sem Aronson, Robert Bakker, Xiaoxia Shi, Suzan Duijst, Lysbeth Bloemendaal, DR Waart, J Verheij, G Ronzitti, Ronald Oude Elferink, Ulrich Beuers, Coen Paulusma, Piter Bosma*. Liver-directed gene therapy results in long-term correction of progressive familial intrahepatic cholestasis type 3 in mice. Journal of Hepatology. 2019 Jul,71(1):153-162.
- Ilan Koppen, Mana Vriesman, Miguel Saps, Shaman Rajindrajith, Xiaoxia Shi, Faridi Etten-Jamaludin, Carlo Lorenzo, Marc Benninga, Merit Tabbers. Prevalence of Functional Defecation Disorders in Children: A Systematic Review and Meta-Analysis. Journal of Pediatrics. 2018 Jul,198:121-130.
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Sem Aronson, Robert Bakker, Sascha Moenis, Remco Dijk, Giulia Bortolussi, Fanny Collaud, Xiaoxia Shi, Suzanne Duijst, Lysbeth Bloemendaal, Giuseppe Ronzitti, Andrés Muro, Federico Mingozzi, Ulrich Beuers, Piter Bosma. A Quantitative In Vitro Potency Assay for Adeno-Associated Virus Vectors Encoding for the UGT1A1 Transgene. Molecular Therapy-Methods & Clinical Development, 2020 Jun 3,18:250-258.
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Xiaoxia Shi*, Giulia Bortolussi*, Fanny Collaud*, Pierre-Romain Lebrun, Lysbeth Bloemendaal, Nicolas Guerchet, Dirk Rudi de Waart, Pauline Sellier, Suzanne Duijst, Philippe Veron, Federico Mingozzi, Takashi Kei Kishimoto, Giuseppe Ronzitti#, Piter Bosma#, Andrés F. Muro#, Repeated dosing of AAV-mediated liver gene therapy in juvenile rat and mouse models of Crigler-Najjar syndrome type I. Molecular Therapy Methods & Clinical Development, 2024.
开设课程
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免疫学（本科生）'
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生物化学与分子生物学实验（本科生）
科研课题
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1. 国家自然科学基金青年项目，2024-2026，主持2. 中国博士后国际交流计划引进项目，2021-2023，主持3. 中国博士后科学基金第70批面上项目，2021-2023，主持4. 球友会博士科研启动项目（自然科学类一档），2024-2026，主持5. 欧盟Horizon 2020计划，2018-2023，参与6. 荷兰科学研究与发展组织（ZonMw）基金项目，2017-2019，参与7. 荷兰Metakids基金项目，2016-2017，参与8. 国家自然科学基金面上项目，2012-2014，参与科研课题
荣誉奖励
2024年入选大连市新引进高层次人才-青年才俊
2023年入选Sigma Xi（英文全称：The Scientific Research Honor Society）美国科学研究荣誉学会正式会员